Publications

Elamipretide Effects in Adults with Primary Mitochondrial Myopathy: Phase 2 Double-Blind, Randomized, Placebo-Controlled Crossover Trial (MMPOWER-2)
By: Karaa A, Haas R, Goldstein A, Vockley G, Cohen BH

Long-Term Safety and Tolerability of elamipretide: The MMPOWER-2 Open-Label Extension Trial
By: By: Amel Karaa, MD, Richard Haas, MD, Amy Goldstein, MD, Jerry Vockley, MD, PhD

Randomized dose-escalation trial of elamipretide in adults with primary mitochondrial myopathy
By: Amel Karaa, MD, Richard Haas, MD, Amy Goldstein, MD, Jerry Vockley, MD, PhD, W. Douglas Weaver, MD, and Bruce H. Cohen, MD
Published By: Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. U.S. Reference: Print ISSN: 0028-3878. Online ISSN: 1526-632X. First Published April 2, 2018.
Publicly available at: http://n.neurology.org/content/90/14/669
National Library of Medicine, National Institutes of Health. Reference: 2018 Apr 3; 90(14):669.

Urinary Metabolite Changes and Correlations with Six Minute Walk Test Distance in Elamipretide-treated Subjects with Mitochondrial Disease in the MMPOWER Trial Abstract #:2018 PA-0443
By: Peter J. Oates, James Carr
Presented at: UMDF – Mitochondrial Medicine 2018 Conference, Nashville TN – June 2018
Publicly available at: https://www.umdf.org/wp-content/uploads/2018/06/UMDF-Scientific-Syllabus-2018.pdf – Page 224

Retrospective Analysis of Healthcare Utilization in Patients with Mitochondrial Disease
By: Bruce H. Cohen, Cristy Balcells, Brian Hotchkiss, Kavita Aggarwal and Amel Karaa

Primary Mitochondrial Myopathy Research: Neurologists Understanding of Primary Mitochondrial Myopathies in Their Patients
By: Mann K, Stanley L, Wall T, DiMatteo M
Published By: Journal of Managed Care & Specialty Pharmacy (JMCP) Reference: Supplement, Vol. 23, No. 10-a, Page 40, October 2017
Publicly available at: https://www.jmcp.org/pb-assets/Poster%20Abstract%20Supplements/Oct2017Abstracts.pdf

Primary Mitochondrial Myopathy Research: Patient Perspectives on Their Journey Through the Healthcare System (Abstract #: 2018 PA-0463)
By: Stanley L, Mann K, Wall T, DiMatteo M
Presented at: UMDF – Mitochondrial Medicine 2018 Conference, Nashville TN – June 2018
Publicly available at: https://www.umdf.org/wp-content/uploads/2018/06/UMDF-Scientific-Syllabus-2018.pdf – Page 235

Elamipretide Improves Skeletal Muscle Function in Elderly Subjects: Results from a Randomized, Double-Blind, Placebo-Controlled, Single IV-Dose Study
By: Conley KE, PhD, Liu Z, PhD, Ali AS, Amory JK, MD, Robertson HL, MD, Goss C, Shankland EG, PhD, Marcinek DM, PhD, and Roshanravan B, MD
Presented at: Heart Failure Society of America 2016.

Mitochondrial-targeted peptide rapidly improves mitochondrial energetics and skeletal muscle performance in aged mice
By: Michael P. Siegel, Shane E. Kruse, Justin M. Percival, Jorming Goh, Collin C. White, Heather C. Hopkins, Terrance J. Kavanagh, Hazel H. Szeto, Peter S. Rabinovitch and David J. Marcinek
Published By: Anatomical Society Journal – The Aging Cell. Reference: Aging Cell. 2013 Oct; 12(5): 763–771.
Published online 2013 Jun 11. doi: [10.1111/acel.12102]
Publicly available at: https://onlinelibrary.wiley.com/doi/full/10.1111/acel.12102
AND
NCBI (National Center for Biotechnology Information) – US National Library of Medicine National Institutes of Health – PubMed Central. References: PMCID: PMC3772966; NIHMSID: NIHMS484140; PMID: 23692570
Publicly available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3772966/

Role of Mitochondrial Dysfunction in Dry Age-Related Macular Degeneration
By: Scott W. Cousins, MD
Published By: Retina Today May/June 2015
Publicly available at: Retina Today
http://retinatoday.com/2015/06/role-of-mitochondrial-dysfunction-in-dry-age-related-macular-degeneration/

A mitochondrial therapeutic reverses visual decline in mouse models of diabetes
By: Nazia M. Alam, William C. Mills IV, Aimee A. Wong, Robert M. Douglas, Hazel H. Szeto and Glen T. Prusky
Published by: The Company of Biologists Ltd | Disease Models & Mechanisms (2015)
Publicly available at biologists.org: http://dmm.biologists.org/content/early/2015/04/22/dmm.020248.short

Phase 2a Clinical Trial of Mitochondrial Protection (Elamipretide) During Stent Revascularization in Patients With Atherosclerotic Renal Artery Stenosis
By: Ahmed Saad, MD; Sandra M.S. Herrmann, MD; Alfonso Eirin, MD; Christopher M. Ferguson, MSc; James F. Glockner, MD, PhD; Haraldur Bjarnason, MD; Michael A. McKusick, MD; Sanjay Misra, MD; Lilach O. Lerman, MD, PhD; Stephen C. Textor, MD
Published By: American Heart Association. Reference: Circ Cardiovasc Interv. 2017 Sep; 10(9): e005487.
Publicly available at: https://www.ahajournals.org/doi/abs/10.1161/CIRCINTERVENTIONS.117.005487?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
AND: NCBI (National Center for Biotechnology Information) – US National Library of Medicine National Institutes of Health – PubMed Central. References: PMCID: PMC5659347
NIHMSID: NIHMS895904; PMID: 28916603 at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659347/
AND: https://www.clinicaltrials.gov. Reference: NCT01755858

Abstract: 1238- MTP131, a cardiolipin targeting peptide, improves mitochondrial activity in the failing human heart
By: B Stauffer, G Sparagna, S Chau, J Rodegheri-Brito, A Ambardekar, A Korst, S Miyamoto, C
Sucharov, K Chatfield, University of Colorado, Medicine/Cardiology Aurora, University of Colorado, Pediatrics/Cardiology Aurora
Published By: European Journal of Heart Failure Reference: Eur J Heart Fail Abstr Suppl 2016;18:289
Publicly available at: European Society of Cardiology at:
https://esc365.escardio.org/Congress/HEART-FAILURE-2016/Rapid-Fire-3-Chronic-heart-failure-management/133477-mtp-131-a-cardiolipin-targeting-peptide-improves-mitochondrial-activity-in-the-failing-human-heart

Guiding Ageing Research Into Maturity
By: Dr. David Marcinek
Published By: Anatomical Society Journal – The Aging Cell
AND:
Scientia -Celebrating Cell Biology and Biochemistry -Volume 110, Page 57
Publicly available at: https://www.scientia.global/dr-david-marcinek-guiding-ageing-research-maturity/

Serendipity and the Discovery of Novel Compounds That Restore Mitochondrial Plasticity
By: HH Szeto and AV Birk
Published By: American Society for Clinical Pharmacology & Therapeutics. Reference: Clin Pharmacol Ther. 2014 Dec; 96(6): 672–683.
Published online 2014 Sep 4. doi: [10.1038/clpt.2014.174]
Publicly available at: https://ascpt.onlinelibrary.wiley.com/doi/abs/10.1038/clpt.2014.174
AND: NCBI (National Center for Biotechnology Information) – US National Library of Medicine National Institutes of Health – PubMed Central. References: PMCID: PMC4267688; NIHMSID: NIHMS647359; PMID: 25188726.  At: https://www.ncbi.nlm.nih.gov/pubmed/25188726