What are mitochondria?

Often described as the “powerhouses of the cell,” mitochondria are responsible for creating more than 90% of the energy our bodies need to sustain life and support growth.13

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they work >

How do
they work?

Healthy mitochondria produce adenosine triphosphate (ATP), the energy molecule required by our bodies' organs to function. This happens through a series of reactions, called the electron transport chain (ETC), within the inner folds of the mitochondria. Under normal conditions, a small amount of reactive oxygen species (ROS) is present in this process.12,21

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Mitochondria & disease

If anything goes wrong during this process, ATP production declines and reactive oxygen species (ROS) goes up. ROS are strong oxidants that can damage the mitochondria and the cell structures of which they are a part.25,41 Learn more >

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Treatment
potential

Our lead investigational compound, elamipretide, is formulated for systemic (subcutaneous injection and intravenous infusion) and topical ophthalmic delivery. Elamipretide is uniquely able to target the inner mitochondrial membrane, restoring electron transport to improve cellular energy production and reduce oxidative stress created by the over-production of ROS.8 Our therapy >

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